The scholar and the unschooled man.--Scholar against scholar.--Scholar and poet.

A commonly used experimental procedure for the study of granulocyte kinetics involves the labelling and subsequent tracing of granulocyte DNA. Following the introduction of a label into the system, observations are made periodically on the concentration of label in the DNA of granulocytes taken from the circulating blood. A mathematical model for the expected value of this concentration has been derived, studied, and related to experimental observations from studies using P32 as a label. Insofar as the derivation of the model (...) accurately incorporates the relevant aspects of granulocyte kinetics, the model will be useful in the interpretation of the experimental observations in terms of these kinetics.Among other things, study of the model indicates that the assumption of “flash” labelling made with respect to some labels is quite crucial and needs to be examined critically. It has also been necessary to make adjustments to allow for the observed emergence of labelled cells from the marrow soon after label introduction. In addition, despite a high degree of confounding of parameter effects it has been possible to suggest bounds on some of the parameters of the model for some species. The bounds will be refined as the model is improved and more data become available. Study and development of the model continues with particular interest in generalizations to include the diseased state chronic granulocytic leukemia. (shrink)

"The Art of Logical Thinking" is a book written by William Walker Atkinson, an American attorney, merchant, publisher, and author in the late 19th and early 20th centuries. The book was first published in 1909 under the pseudonym Theron Q. Dumont, one of Atkinson's many pen names. The primary focus of "The Art of Logical Thinking" is to provide readers with insights into developing and refining their logical thinking abilities. Atkinson explores various aspects of logical reasoning and critical (...) thinking, aiming to guide readers in making better decisions, solving problems, and approaching issues with a more rational mindset. Key topics covered in the book include: The Nature of Thought: Atkinson delves into the fundamentals of thought processes, examining how ideas are formed and how the mind operates in its thinking capacity. Logical Analysis: The book provides techniques for breaking down complex problems into smaller, more manageable components, facilitating a systematic and logical approach to problem-solving. Deductive and Inductive Reasoning: Atkinson discusses both deductive and inductive reasoning, explaining their principles and applications. Deductive reasoning involves drawing specific conclusions from general principles, while inductive reasoning involves deriving general principles from specific observations. (shrink)

William Tait is one of the most distinguished philosophers of mathematics of the last fifty years. This volume collects his most important published philosophical papers from the 1980's to the present. The articles cover a wide range of issues in the foundations and philosophy of mathematics, including some on historical figures ranging from Plato to Gdel.

This book is an outgrowth of a series of articles originally published in The Progress Magazine under a pseudonym, in which I sought to account for the prevailing mental unrest regarding subjects of religious and philosophical import. These articles attracted much attention from careful students of the times, and there have been many requests for the republication thereof in book form under my own name. Accordingly, the publishers of the articles requested me to revise the several papers, and to add (...) thereto such further matter as I might think proper. I have gone over the original articles, taking away a little here and adding much there. Several entirely new subjects have been considered and inserted in their proper places in the text. At least one third of the present book is entirely new, having been added to the revised form of the original articles. I have purposely quoted freely from good authorities, that the reader may have the benefit of the thought of a number of competent persons upon the various phases of the subject, in addition to what I have personally thought and written. I have sought merely to tell my story in a plain, simple manner, without any attempt at fine writing, literary excellence, or display of technical philosophical knowledge. My desire has been to place in the hands of the everyday busy man and woman a book from the pages of which they may gain a general knowledge of the causes of the modern mental unrest-an idea of what is going into this great melting pot of thought; what is happening there; and what is likely to be poured forth from it. To many, the numerous new "isms," "ologies" and cults, are entirely new- something sprung full grown from the brains of their founders. The absence of an elementary acquaintance with the history of philosophy, on the part of the average man and woman, has given to many new prophets and founders of cults an unmerited and unwarranted importance and authority. I trust that this book will enable some of those who have been perplexed and worried over these new (?) "isms," and teachings, to learn the true sources of those startling conglomerations of metaphysics, philosophy and theology, and thus once more to regain their mental bearings. It is also my hope that some who have a tendency toward philosophical study may be inspired by this book to go to the proper sources of such knowledge-to the masters of this branch of thought-instead of sitting at the feet of the, too often, freakish, irresponsible, and bizarre founders and teachers of the pseudo schools and cults, who have been revamping the old teachings, dressing them in fantastic garb, and offering them (usually at a high rate of compensation) to those who have felt the hunger for wisdom and the thirst for information, but who lacked the knowledge of the places where these things could be had at first hand, pure and free from the adulterations of these self constituted middle men in the great market of Philosophy. (shrink)

We investigated the properties of the sustained attention to response task . In the SART, participants respond to frequent neutral signals and are required to withhold response to rare critical signals. We examined whether SART performance shows characteristics of speed–accuracy tradeoffs and in addition, we examined whether SART performance is influenced by prior exposure to emotional picture stimuli. Thirty-six participants in this study performed SARTs after being exposed to neutral and negative picture stimuli. Performance in the SART changed rapidly over (...) time and there was a high correlation between participants errors of commission rate and their reaction time to the neutral targets . Regardless of exposure self-reported thoughts significantly correlated with both errors of commission and reaction times. Overall, the results support the view that the SART is a better measure of impulsive responding than sustained attention. (shrink)

The dynamics of populations of self-replicating, hierarchically structured individuals, exposedto accidents which destroy their sub-units, is analyzed mathematically, specifically with regardto the roles of redundancy and sexual repair. The following points emerge from this analysis:0 A population of individuals with redundant sub-structure has no intrinsic steady-statepoint; it tends to either zero or infinity depending on a critical accident rate α c . Increased redundancy renders populations less accident prone initially, but populationdecline is steeper if a is greater than a fixed (...) value α d . Periodic, sexual repair at system-specific intervals prevents continuous decline and stabilizesthe population insofar as it will now oscillate between two fixed population levels. The stabilizing sexual interval increases with increased complexity provided this is accom-panied by appropriate levels of redundancy. The model closely simulates the dynamics of heterosis effects. Repair fitness is a population fitness: the chance of an individual being repaired is a functionof the statistical make-up of the population as a whole at that particular period. Populationsliving at α > α c either engage in sexual repair at the appropriate time or they die out. The mathematical properties of the model illustrate mechanisms which possibly played arole in the evolution of a mortal soma in relation to sexual reproduction. (shrink)

In their article “Three Kinds of Decision-Making Capacity for Refusing Medical Interventions,” Navin et al. (2022) argue that we should recognize two forms of decision-making capacity (DMC) besides...

A simple model, illustrating the transition from a population of free swimming, solitary cells to one consisting of small colonies serves as a basis to discuss the evolution of the cooperative group. The transition is the result of a mutation of the dynamics of cell division, delayed cell separation leads to colonies of four cells. With this mutation cooperative features appear, such as synchronised cell divisions within colonies and coordinated flagellar function which enables the colony to swim in definite directions. (...) The selective advantages under given, environmental conditions are defined and the periods necessary for complete allelic replacement in small populations are calculated for asexual and sexual reproduction. The assumption of a steady-state population during allelic substitution is critically considered, particularly under conditions of competition. It is shown that density-dependent population control must operate in the process of selection. Sexual reproduction slows down the rate of selection even though all cells dre haploid. This phenomenon can be explained in general terms of `organizational dominance', where individual units coordinate the function of their neighbours which may be of a different allelotype.Cooperativity is pointed out as an a priori systemic feature which resides in the sub-units of systems, group formation and coordination appears thus as an almost inevitable event. A particular type of system described as ‘closed cycle of positive fitness interaction’ is discussed in more detail. It has the remarkable feature that its members cannot compete with each other; selection takes place between whole cycles .Gonium has a wide spectrum of `somatic plasticity' which enables it to assume various colonial configurations depending on physiological and environmental conditions. This feature can be explained as the result of dynamic flexibilities on the macro-molecular level. The particular relationship between the vast, molecular complexity and the relative simple dynamics of the cell cycle must lead eventually to the genetic fixation of an environmentally induced phenotype. (shrink)

Given the apocalyptic nature of nuclear weapons, how can states establish an international order that ensures survival while allowing the weapons to be used in controlled ways to discourage great wars, and while allowing nuclear technology to diffuse for civil purposes? How can the possession of nuclear weapons by a few states be reconciled with their renunciation by the majority of states? Which political strategies can best deliver an international nuclear order that is effective, legitimate and durable? These have been (...) central questions in the nuclear age. This article suggests that the effort to construct such an order displayed the characteristics of an enlightenment project, with its emphasis on balance and rationality, the quest for justice and trust among states, the feasibility of instrumental regulation, and the attachment to hope and progress. With the Nuclear Non-Proliferation Treaty at its heart, it necessarily gave precedence to diplomacy and containment over preventive war. The reasons why this conception of nuclear order was discarded by its erstwhile champion, the United States, in favor of one bearing traits of counter-enlightenment, are explored. Its alternative strategy can now be declared a failure. Avoidance of a greater disorder depends on recognition that the problem of nuclear order is more than the problem of proliferation, or of non-compliance, and on recovery whatever the difficulties of the cooperative yet pragmatic sensibility that lay behind the prior approach to order. (shrink)

William Walker's original analysis of John Locke's An Essay Concerning Human Understanding offers a challenging and provocative assessment of Locke's importance as a thinker, bridging the gap between philosophical and literary-critical discussion of his work. He presents Locke as a foundational figure who defines the epistemological and ontological ground on which eighteenth-century and Romantic literature operate and eventually diverge. He is revealed as a crucial figure for emerging modernity, less the familiar empiricist innovator and more the proto-Nietzschean thinker (...) whose text fosters hitherto unsuspected instabilities and promotes a new kind of rhetorical force to counterbalance them. Walker's reading of Locke is at once finely attentive to the text and engagingly resourceful in placing the Essay in its broadest philosophical and historical context. (shrink)

Some of the founding documents of our modern human rights culture assert that, by virtue of natural law, the will of God, the will of a Supreme Being, or some kind of natural world order, all humans have a right to civil liberties. In Areopagitica, Milton rejects this way of grounding the claim to civil liberties. Instead, he argues for civil liberties on pragmatic grounds, but also on the premise that members of political societies are entitled to civil liberties from (...) their governors only insofar as those members are rational and virtuous. His argument for civil liberties is also grounded in the view that the proper function of government includes propagating virtue in those it governs, assessing their rationality and moral virtue, and extending civil liberties to them in accordance with this assessment. Arguing in this way, Milton opposes the notion that, simply by virtue of being human, all members of political societies have a specific set of rights which their governments, and indeed all other people on earth, are bound to respect. He thus has more in common with Isocrates and Renaissance humanists than he does with the defenders of our modern human rights culture. (shrink)

In the major political prose works which he published from 1649 to 1654, Milton argues that it was not the parliamentarians but Charles Stuart and his supporters who were the real rebels during the wars of the 1640s. He claims that during this period, the parliamentarians did not fight to overturn law, church, and government, but to preserve peace, to maintain the old, orthodox form of Christianity which had only partially been re-established in England, and to defend English law and (...) the civil liberties it safeguarded. He disavows any hostility to true monarchy and asserts the right of all peoples to choose for themselves whatever form of government they wish. He argues that, since by 1649 Charles Stuart had long been deposed, there was no regicide but merely a legal execution, one which was also consistent with the ancient constitution of England and the political thought of the champion of ancient Roman laws and customs, Cicero. All of this supports several recent accounts of Interregnum political thought and rhetoric and challenges much of the work, from Christopher Hill on, which makes Milton out to be a radical. (shrink)

This article provides an account of what may reasonably be inferred from Sallust’s historical writing about how he understands civil liberty, what he feels is necessary for it to exist in any given political society, why he feels it is important, and the extent to which he feels it is properly enjoyed by the plebeian citizens of Rome. On the basis of this account, the article revises recent arguments presented by Quentin Skinner, Philip Pettit and others concerning Sallust’s political thought (...) and how it is related to Aristotelian, republican, ‘neo-Roman’, and liberal traditions of political thought. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Machiavellian Rhetoric: From the Counter-Reformation to MiltonWilliam WalkerMachiavellian Rhetoric: From the Counter-Reformation to Milton, by Victoria Kahn; xv & 3l4 pp. Princeton: Princeton University Press, 1994, $29.95.The premise of this book is that the account of Machiavelli’s politics given by Quentin Skinner and J. G. A. Pocock is fundamentally inadequate. It is inadequate in that it fails to recognize that the Machiavelli of force and fraud—what Kahn calls (...) the “rhetorical Machiavel”—is inseparable from the republican, and that his politics “could be used not only pro and contra republicanism but pro and contra secular thought” (p. 12). This failure is answerable to a flawed methodology: reading Machiavelli’s texts for content, Skinner and Pocock neglect Machiavelli’s rhetorical techniques which “fragment, subvert, or otherwise qualify the literal sense” of his texts (p. 5). By paying attention to these rhetorical techniques, Kahn claims to correct Skinner and Pocock’s misunderstanding of Machiavelli as a virtuous, secular republican and “to provide a revised history of Renaissance Machiavellism, particularly in England” (p. 4).The main reason for the failure of this project is Kahn’s crude understanding of Skinner and Pocock. Rather than seeing Machiavelli assimilating virtù with classical virtue, Skinner observes that Machiavelli’s exclusion of justice from republican virtù is an epoch-making break with the classical republican analysis of the cardinal virtues as expounded in Cicero’s Of Duties. Pocock, too, clearly recognizes that Roman republican virtù as it is documented by Machiavelli includes what Kahn calls “the resources of the Machiavel” (p. 124). In addition, rather than equating Machiavellism with secular republicanism, Pocock observes that it was difficult for not just Machiavelli but everyone in the Renaissance to conceive the moment of recreating the republic without making recourse to the apocalyptic moment, the moment at which grace acted in history. And to think as Kahn does that Pocock needs to be told that Machiavellism could be “used for sectarian religious purposes” (p. 8) is simply to disregard Pocock’s own assertion of this fact and his tremendous meditation on how this actually occurred in the millennially oriented society of seventeenth-century England.The claims which Kahn makes on the basis of her perceptive close readings [End Page 370] of the rhetoric of Machiavelli’s The Prince and The Discourses, then, do not significantly revise Pocock and Skinner. Neither do her considerations of readings of Machiavelli by counter-Reformation thinkers such as Zuccolo, Caterino, and Botero, sixteenth-century Englishmen such as Starkey, Gardiner, Ralegh, Bacon, and Shakespeare, and the seventeenth-century Englishmen who were involved in civil war and Interregnum political debates. These considerations simply make the point that Machiavelli was read in very different ways and was used to support very different political agendas—an interesting point, and one which is entirely consistent with the views of Skinner and Pocock. Kahn’s revised history of English Machiavellism is further compromised by her construal, beginning in chapter five, of Machiavellism as “the Machiavellian topics of legitimacy and force, virtue and success, intention and effect, means and ends” (p. 156). Kahn seems to suppose that because Machiavelli writes about these topics, these topics are Machiavellian, and anyone who writes about them in English is therefore a subscriber to “English Machiavellism.” This move allows her to consider all kinds of texts which only seem remotely connected to Machiavelli—from sixteenth-century debates over things indifferent, to Coriolanus, to masques by Jonson and Carew, to Milton’s Areopagitica, Comus, and Paradise Lost—as cases of “English Machiavellism.” Kahn ends up defining Machiavellism so widely, that is, that she finds it everywhere. On the other hand, she ignores it where it is most conspicuous: she gives passing attention to Marchamont Nedham’s fully articulated republicanism and no attention whatsoever to the most comprehensive English reading of Machiavelli in the seventeenth century: James Harrington’s Oceana.A revised history of Renaissance Machiavellism, particularly in England? Hardly. Skinner and Pocock still rule.William WalkerUniversity of Canterbury, New ZealandCopyright © 1995 The Johns Hopkins University Press... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Professional Correctness: Literary Studies and Political ChangeWilliam WalkerProfessional Correctness: Literary Studies and Political Change, by Stanley Fish; xi & 146 pp. Oxford: Clarendon Press, 1995, $22.00 paper.Our greatest living Miltonist, Professor Fish, continues to address the most hotly contested issues of the profession of literary criticism in prose which, if perhaps not quite the best in Anglo-American literary studies as he once judged it to be, is certainly (...) distinguished by coherence, power, and wit. In this version of material he presented in a workshop at the Folger Library in 1990 and as the Clarendon Lectures at Oxford University in 1993, Fish analyzes the relationship between literary criticism and political change. By literary criticism, he means the activity of determining what a literary text means. According to Fish, while in the eighteenth century just about any kind of commentary on literature counted as literary criticism, the determination of the meaning of literature is the essential job of literary criticism in the twentieth century. By political change, Fish means changes in things such as the way governments spend money, treat their citizens and foreign governments, establish the civil law, and appoint people to office. The major claim of the book is that doing literary criticism in the United States today rarely causes political change. The counsel he offers to all those literary critics who want to bring about political change through their literary work is thus to find a new job: “if you want to send a message that will be heard beyond the academy, get out of it” (p. 2).But why can’t observing that Lycidas means that Milton is afraid of women help to overthrow patriarchy and the legal/cultural system which continues to perpetuate it? Because, Fish claims, “there are, at present, no well-established routes by which literary criticism is first brought to the attention of those who inhabit the centers of power and then presented to them in a way that ties it to their concerns” (p. 52). That is to say that it is because American society is structured in a particular way that literary interpretive acts are politically inconsequential. Though he does not provide much evidence for this big claim about the structure of American society and its relation to literary criticism, Fish does support it by asking us to see the absurdity of imagining otherwise: “think about it. You are about to open a new business or introduce a bill in Congress or initiate an advertising campaign, but you pause to ask yourself, ‘What would the readers of Diacritics say?’” (p. 91). This is not to say that the segregation of literary work from political work is a given of the human condition. Fish cites Renaissance England and contemporary Israel as cases of societies structured in such a way that literary acts have immediate and important political consequences (though literary acts and political acts in these societies are still clearly distinct because their purposes are still different). The point is just that, because American society is currently structured as it is, the activity of identifying the meaning of works of literature is rarely [End Page 544] relevant to political change. The point holds even when one shifts the center of literary work from determining the meaning of literature to (i) observing how literature and the act of professing it are deeply implicated in society-wide structures of power and legitimization, or (ii) observing and “transcending” the boundaries between literary criticism and other disciplines. That is to say that even if one were to transform literary criticism in the way new historicists and several proponents of cultural studies whom Fish cites propose, work in this discipline would still rarely cause significant political change. For the contingent fact is that, regardless of what academics do, think they do, and intend to do, “no one cares very much about literary criticism outside the confines of its professional practice” (p. 55).But if literary criticism cannot, at least for the moment in the U.S., do significant political work, and if, as Fish also claims, it cannot do significant moral, cultural work (making people better, preserving the best that is said... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Reason and Rhetoric in the Philosophy of HobbesWilliam WalkerReason and Rhetoric in the Philosophy of Hobbes, by Quentin Skinner; xvi & 477 pp. Cambridge: Cambridge University Press, 1996, $49.95.Having shown in his earlier work how the classical Roman texts on rhetoric governed to an important extent the formulation of republican ideas in Italian Renaissance and therefore modern political thought, Skinner now returns to these texts in order to (...) treat more comprehensively one of the major subjects of his research over the last thirty years—Thomas Hobbes. Determined to understand not so much what Hobbes’s writings mean as what Hobbes is doing, what “traditions he reacts against, what lines of argument he takes up, what changes he introduces into existing debates” (p. 8), Skinner devotes the entire first half of the book to “classical eloquence in Renaissance England” (p. 17). Citing mainly the Ad Herennium and the texts on rhetoric by Cicero and Quintilian, he provides a superb account of the classical Roman theory of persuasive speaking, as well as the ideal of citizenship which underlies it: for the Romans, the vir civilis, the good citizen, is the virtuous, wise, rational man [End Page 204] who exercises his mastery of the art of rhetoric to serve his community by pleading for just verdicts in the courts and beneficial policies in the assemblies. Citing the Tudor humanists who were instituting and teaching at the grammar schools, but also several sixteenth- and seventeenth-century English rhetoricians, poets, and prose writers, Skinner then observes how this classical theory of persuasion and its ideal of citizenship achieved “widespread currency” (p. 1) in England and served as the foundation for “the rhetorical culture of Renaissance humanism” (p. 250).It is in relation to this culture, Skinner insists in the second part of the book, that Hobbes must be understood. For although, as many have pointed out, Hobbes’s thinking was in part formed by the scientific developments of the century, “his intellectual formation was overwhelmingly indebted not to the culture of science but to the humanist literary culture” (p. 216). But this is not to say that Hobbes abides peacefully within this culture. After observing how his education, career, and publications up to 1640 are those of the “typical Renaissance humanist” (p. 217), Skinner argues that in his two major works of the early 1640s, Hobbes powerfully repudiates the entire classical theory of eloquence and its ideal of the vir civilis. For in The Elements of Law and De Cive, Hobbes claims to have made the study of moral and political theory into a scientific discipline. On the basis of this assertion, Skinner argues, Hobbes claims that reason unaided by eloquence is sufficient to persuade others of the truths of civil science, that eloquent men have not sustained but destroyed civil life, and that the most important duties of citizenship lie in the private sphere. In short, “Hobbes’s argument culminates in a view of citizenship and its obligations diametrically opposed to the image of the vir civilis” (p. 291). He does so, moreover, in prose which studiously avoids the invocation of commonplaces and authorities, the establishment of any ethos, the manipulation of definitions, the redescription of vices as virtues and virtues as vices (paradiastole), and the tropes and figures—Hobbes practices the repudiation of rhetoric he preaches.But then there is Leviathan (1651). Responding primarily out of his understanding of how Presbyterian and House of Commons demagogues incited civil war, Hobbes in his most celebrated work “reverts to the typically humanist assumption that, if we are to succeed in persuading others to accept our arguments, we shall have to supplement the findings of reason with the moving force of eloquence” (p. 426). Though he continues to understand himself transforming politics and morality into a scientific discipline, Hobbes ultimately reaffirms the premises of the rhetorical culture that produced him and that he repudiated in his first major political works. And though he continues to be critical of commonplaces, reliance on authorities, and tropes and figures, Hobbes in this work again practices what he preaches. In the final chapter of the book, Skinner meticulously documents how Hobbes uses the tropes and... (shrink)

Researchers often lack the necessary data to credibly estimate racial discrimination in policing. In particular, police administrative records lack information on civilians police observe but do not investigate. In this article, we show that if police racially discriminate when choosing whom to investigate, analyses using administrative records to estimate racial discrimination in police behavior are statistically biased, and many quantities of interest are unidentified—even among investigated individuals—absent strong and untestable assumptions. Using principal stratification in a causal mediation framework, we derive (...) the exact form of the statistical bias that results from traditional estimation. We develop a bias-correction procedure and nonparametric sharp bounds for race effects, replicate published findings, and show the traditional estimator can severely underestimate levels of racially biased policing or mask discrimination entirely. We conclude by outlining a general and feasible design for future studies that is robust to this inferential snare. (shrink)

Suicidal Thoughts is a compilation of some of the most moving and insightful writing accomplished on the topic of suicide. It presents the thoughts and experiences of fifteen writers who have contemplated suicide-some on a professional level, others on a personal level, and a few, both personally and professionally. Through this collection, the reader is able to bear witness to the struggle between life and death and to the devastating aftermath of suicide. Suicidal Thoughts provides readers with a better understanding (...) of the reasons why some individuals give serious consideration to killing themselves. (shrink)